Preferred Label : Quadrivalent Human Papillomavirus (types 6, 11, 16, 18) Recombinant Vaccine;
NCIt synonyms : Recombinant Human Papillomavirus (HPV) Quadrivalent Vaccine; Quadrivalent Human Papillomavirus Recombinant Vaccine; Quadrivalent HPV [Type 6, 11, 16 and 18] L1 Virus-Like Particle vaccine;
NCIt related terms : quadrivalent human papillomavirus (types 6, 11, 16, and 18) recombinant vaccine; Gardasil;
NCIt definition : A non-infectious recombinant, quadrivalent vaccine prepared from the highly purified
virus-like particles (VLPs) of the major capsid (L1) protein of human papillomavirus
(HPV) types 6, 11, 16, and 18 with immunoprophylactic activity. L1 proteins are produced
by separate fermentations in recombinant Saccharomyces cerevisiae, self-assembled
into VLPs, and adsorbed onto amorphous aluminium hydroxyphosphate sulfate adjuvant
following purification. The immunoprophylactic efficacy of L1 VLP vaccines, such as
quadrivalent human papillomavirus (types 6,11,16,18) recombinant vaccine, appear to
be mediated by the development of humoral immune responses. HPV Types 16 and 18 account
for approximately 70% of cervical cancers and HPV Types 6 and 11 account for approximately
90% of genital warts.;
Alternative definition : NCI-GLOSS: A vaccine used to prevent cervical, vulvar, and vaginal cancer caused by
human papillomavirus (HPV) types 16 and 18 and genital warts caused by HPV types 6
and 11. It is also used to prevent lesions that are caused by these viruses and that
can lead to cervical, vulvar, or vaginal cancer. Quadrivalent human papillomavirus
(types 6, 11, 16, and 18) recombinant vaccine is used in females aged 9-26 years.
It is also used to prevent genital warts in males aged 9-26 years. Quadrivalent human
papillomavirus (types 6, 11, 16, and 18) recombinant vaccine is being studied in the
treatment of other medical conditions.;
Drug name : Gardasil;
Molecule name : V501;
Codes from synonyms : CDR0000661955; CDR0000661954;
Origin ID : C61087;
UMLS CUI : C1831799;
Automatic exact mappings (from CISMeF team)
- CISMeF manual mappings
- Semantic type(s)
- UMLS correspondences (same concept)
- chemical_or_drug_affects_cell_type_or_tissue
- chemical_or_drug_has_mechanism_of_action
- chemical_or_drug_has_physiologic_effect
- concept_is_in_subset
