Preferred Label : Autologous Cytoplasmic Activated PD-1 CAR T-cells;
NCIt synonyms : Autologous CAR19 T-cells Carrying Cytoplasmic Activated PD-1;
NCIt definition : A preparation of autologous T-lymphocytes engineered to express a chimeric antigen
receptor (CAR) specific for the tumor-associated antigen (TAA) cluster of differentiation
19 (CD19), carrying cytoplasmic activated programmed cell death 1 (PD1; PDCD1; CD279;
programmed death-1), with potential antineoplastic activity. Upon intravenous administration,
autologous cytoplasmic activated PD-1 CAR T-cells target, bind to, and induce selective
toxicity in CD19-expressing tumor cells. The cytoplasmic activated PD1, a negative
immunoregulatory human cell surface receptor, normally binds to programmed cell death-1
ligand 1 (PD-L1; cluster of differentiation 274; CD274) on tumor cells, causing T-cell
inactivation. By preventing PD1/PD-L1 signaling, T-cell exhaustion is abrogated, and
T-cell activation is enhanced leading to an increased cytotoxic T-lymphocyte (CTL)-mediated
anti-tumor immune response against PD-L1-expressing tumor cells. CD19 is a B-cell-specific
cell surface antigen overexpressed in B-cell lineage tumors.;
NCI Metathesaurus CUI : CL938080;
Origin ID : C158599;
UMLS CUI : C4764285;
Semantic type(s)
- Cell [UMLS semantic type]
- chemical_or_drug_affects_cell_type_or_tissue
- chemical_or_drug_has_mechanism_of_action
- chemical_or_drug_has_physiologic_effect
- concept_is_in_subset
