" /> Autologous Anti-BCMA-CAR-expressing CD4 /CD8 T-lymphocytes FCARH143 - CISMeF





Preferred Label : Autologous Anti-BCMA-CAR-expressing CD4 /CD8 T-lymphocytes FCARH143;

NCIt synonyms : Autologous Anti-BCMA-CAR CD4 /CD8 Cells; BCMA CAR-CD4 /CD8 T-cells; BCMA-specific CAR-expressing CD4 /CD8 T-lymphocytes; Autologous Anti-BCMA-CAR-expressing CD8 and CD4 T-lymphocytes;

NCIt definition : A preparation of ex vivo expanded autologous CD8 and CD4 T-cells that have been genetically modified to express a chimeric antigen receptor (CAR) specific for human B-cell maturation antigen (BCMA; tumor necrosis factor receptor superfamily member 17; TNFRSF17), with potential immunostimulating and antineoplastic activities. Upon administration, autologous anti-BCMA-CAR-expressing CD4 /CD8 T-lymphocytes FCARH143 specifically recognize and induce selective toxicity in BCMA-expressing tumor cells. BCMA, a tumor specific antigen and a receptor for both a proliferation-inducing ligand (APRIL) and B-cell activating factor (BAFF), is a member of the tumor necrosis factor (TNF) receptor superfamily (TNFRSF) and plays a key role in plasma cell survival. BCMA is found on the surfaces of plasma cells and overexpressed on malignant plasma cells.;

Molecule name : FCARH143;

NCI Metathesaurus CUI : CL540710;

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12/05/2024


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