Preferred Label : Autologous CD38-4SCAR-expressing T-cells 4SCAR38;
NCIt synonyms : 4SCAR38 T-cells; Anti-CD38 CAR-T Cells 4SCAR38; CD38-4SCAR-expressing T Lymphocytes; Anti-CD38-CD28-CD137-CD27-CD3z-iCasp9 CAR T-cells 4SCAR38; 4S-CD38-CAR-T Cell; CD38-scFv/CD28/CD137/CD27/CD3z-iCasp9 T-cells; CD38-specific 4th Generation Chimeric Antigen Receptor-modified T Cells;
NCIt definition : A preparation of genetically modified autologous T-cells transduced with a replication
incompetent, self-inactivating lentiviral vector expressing a fourth generation chimeric
antigen receptor (4SCAR) consisting of an anti-CD38 single chain variable fragment
(scFv) that is coupled to the costimulatory signaling domains CD28, CD137, CD27 and
the zeta chain of the T-cell receptor (TCR), and is fused with the suicide gene inducible
caspase 9 (iCasp9), with potential immunostimulating and antineoplastic activities.
Upon intravenous administration, autologous CD38-4SCAR-expressing T-cells 4SCAR38
are directed to and induce selective toxicity in CD38-expressing tumor cells. iCasp9
consists of a human FK506 drug-binding domain with an F36V mutation (FKBP12-F36V)
linked to human caspase 9. If the administered T-cells lead to unacceptable side effects,
the chemical homodimerizer AP1903 can be administered. AP1903 binds to the drug binding
FKBP12-F36V domain and induces activation of caspase 9, which results in the apoptosis
of the administered T-cells and enhances safety of this agent. CD38, a type II transmembrane
glycoprotein, is present on various immune cells and hematologic malignancies, and
its expression has been correlated with poor prognosis. CD28, CD137 and CD27, T-cell
surface-associated co-stimulatory molecules, are required for full T-cell activation
and enhance both proliferation of T-cells and antitumor activity.;
Molecule name : 4SCAR38;
NCI Metathesaurus CUI : CL551145;
Origin ID : C148523;
UMLS CUI : C4725099;
Semantic type(s)
- Cell [UMLS semantic type]
- chemical_or_drug_affects_cell_type_or_tissue
- chemical_or_drug_has_mechanism_of_action
- chemical_or_drug_has_physiologic_effect
- concept_is_in_subset
