Autologous Blinatumomab-expanded T-Cells

Preferred Label : Autologous Blinatumomab-expanded T-Cells;

NCIt synonyms : Blinatumomab-cultured T cells; BET; Blinatumomab-expanded T Cells; Blinatumomab-expanded Peripheral Blood-derived T Cells;

NCIt definition : A preparation of autologous, peripheral blood-derived polyclonal activated T-cells that have been expanded and activated ex-vivo using blinatumomab and recombinant human IL2 (rhIL-2) and depleted of contaminating CD19 tumor cells, with potential immunomodulating activity. Upon administration, these blinatumomab-expanded T-cells (BET), composed of functional polyclonal CD4 and CD8 T-cells and mostly effector and central memory cells, may induce immunological recovery. BET cell expansion leads to the lysis and elimination of contaminating CD19 tumor cells. The elimination of contaminating tumor cells is important in the treatment of non-Hodgkin CD20 indolent lymphoma (iNHL) and chronic lymphatic leukemia (CLL).;

NCI Metathesaurus CUI : CL1383300;

Details

Origin ID

C170899;

UMLS CUI

C5401387;

Automatic exact mappings (from CISMeF team)
- beta vulgaris [MeSH Descriptor]
- microporous carbon [IUPAC Term]
Semantic type(s)
- Cell [UMLS semantic type]
chemical_or_drug_affects_cell_type_or_tissue
- Cytotoxic T-Lymphocyte [NCIt concept]
chemical_or_drug_has_mechanism_of_action
- Antigen Sensitization [NCIt concept]
chemical_or_drug_has_physiologic_effect
- Immunopotentiation [NCIt concept]
- T-Cell Activation [NCIt concept]
concept_is_in_subset
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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