Autologous E6 T Cell Receptor Genetically-modified T Cells

Preferred Label : Autologous E6 T Cell Receptor Genetically-modified T Cells;

NCIt synonyms : Autologous HPV-16 E6 TCR T Cells; Autologous Anti-HPV-16 E6 TCR T Cells; Autologous E6 TCR T-cells; Autologous E6 TCR T Cells;

NCIt definition : A preparation of human autologous peripheral blood lymphocytes (PBLs) that have been genetically engineered to express a T-cell receptor (TCR) that specifically targets the viral oncoprotein human papillomavirus type 16 (HPV-16) E6, with potential antineoplastic activity. Upon administration, the HPV E6 TCR genetically-modified T-cells target and bind to HPV-16 E6-expressing tumor cells, which leads to specific cytotoxic T-lymphocyte (CTL)-mediated killing of HPV-16 E6-positive tumor cells. HPV-16 E6, a cell surface glycoprotein, plays a key role in the tumorigenesis of various HPV-associated tumors and is absent from healthy human tissues.;

NCI Metathesaurus CUI : CL553275;

Details

Origin ID

C151936;

UMLS CUI

C4726563;

Semantic type(s)
- Cell [UMLS semantic type]
chemical_or_drug_affects_cell_type_or_tissue
- Cytotoxic T-Lymphocyte [NCIt concept]
chemical_or_drug_has_mechanism_of_action
- Antigen Sensitization [NCIt concept]
chemical_or_drug_has_physiologic_effect
- Immunopotentiation [NCIt concept]
- T-Cell Activation [NCIt concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Protein E6, Human Papillomavirus Type 16 [NCIt concept]

Keyword's position in hierarchy(ies) :

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