gp100 and GM-CSF DNA/Gold Vaccine

Preferred Label : gp100 and GM-CSF DNA/Gold Vaccine;

NCIt synonyms : gp100 GM-CSF DNA/Gold; gp100 and GM-CSF DNA-Gold Vaccine;

NCIt definition : A vaccine consisting of microscopic gold particles coated with plasmid DNA encoding the glycoprotein 100 (gp100) melanoma antigen and granulocyte-macrophage colony-stimulating factor (GM-CSF). Vaccination with gp100 and GM-CSF DNA/gold vaccine may stimulate the host immune system to direct cytotoxic T lymphocytes (CTL) against gp100 positive cells, resulting in decreased tumor growth. GM-CSF is thought to increase the induction and activation of antigen-presenting cells (APC), allowing for a reduction in the dose of gp100 administered. (NCI04);

NSC code : 708479;

Details

Origin ID

C2760;

UMLS CUI

C1515640;

Semantic type(s)
- Immunologic Factor [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
chemical_or_drug_affects_abnormal_cell
- Melanoma Cell [NCIt concept]
chemical_or_drug_affects_cell_type_or_tissue
- Cytotoxic T-Lymphocyte [NCIt concept]
chemical_or_drug_has_mechanism_of_action
- Gene Regulation Process [NCIt concept]
chemical_or_drug_has_physiologic_effect
- Cytokine Receptor Activation [NCIt concept]
- Immunopotentiation [NCIt concept]
- Myeloid Cell Activation Process [NCIt concept]
- T-Cell Activation [NCIt concept]

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