Autologous Anti-DLL3 CAR-T Cells LB2102

Preferred Label : Autologous Anti-DLL3 CAR-T Cells LB2102;

NCIt synonyms : Autologous Anti-DLL3 CAR T Cells LB2102; Autologous DLL3-directed CAR T-cells LB2102;

NCIt definition : A preparation of autologous T-lymphocytes that have been genetically engineered to express a chimeric antigen receptor (CAR) specific for the tumor-associated antigen (TAA) delta-like protein 3 (DLL3), with potential immunomodulating and antineoplastic activities. Upon administration, autologous anti-DLL3 CAR-T cells LB2102 recognize and induce selective toxicity in DLL3-expressing tumor cells. DLL3, a Notch pathway protein, is overexpressed on a variety of cancer cell types. It plays a key role in embryonic development and in tumor initiation and proliferation.;

Molecule name : LB-2102; LB 2102;

NCI Metathesaurus CUI : CL1906533;

Details

Origin ID

C199628;

chemical_or_drug_affects_cell_type_or_tissue
- Cytotoxic T-Lymphocyte [NCIt concept]
chemical_or_drug_has_mechanism_of_action
- Antigen Sensitization [NCIt concept]
chemical_or_drug_has_physiologic_effect
- Immunopotentiation [NCIt concept]
- T-Cell Activation [NCIt concept]
concept_is_in_subset
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Delta-Like Protein 3 [NCIt concept]

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