" /> Equecabtagene Autoleucel - CISMeF





Preferred Label : Equecabtagene Autoleucel;

NCIt synonyms : Autologous Anti-BCMA CAR-T Cells CT103A; Autologous Anti-BCMA CAR-transduced T-cells CT103A; Autologous Anti-BCMA CAR T Cells CT103A;

NCIt definition : A preparation of autologous T-lymphocytes that have been transduced with a lentiviral vector expressing a chimeric antigen receptor (CAR) with a fully human single chain variable fragment (scFv) targeting the human tumor-associated antigen (TAA) B-cell maturation antigen (BCMA; tumor necrosis factor receptor superfamily member 17; TNFRSF17), with potential immunostimulating and antineoplastic activities. Upon administration, equecabtagene autoleucel specifically recognize and induce selective toxicity in BCMA-expressing tumor cells. BCMA, a receptor for both a proliferation-inducing ligand (APRIL) and B-cell activating factor (BAFF), is a member of the tumor necrosis factor receptor superfamily (TNFRSF). BCMA is found on the surfaces of plasma cells, is overexpressed on malignant plasma cells, and plays a key role in plasma cell proliferation and survival.;

UNII : YTJ3XRJ4ZN;

Molecule name : CT 103A; CT-103A;

NCI Metathesaurus CUI : CL1773470;

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15/05/2024


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