NCIt definition : A preparation of tumor infiltrating lymphocytes (TILs) that are transduced with a
retroviral vector encoding a gene for a dominant-negative form of the transforming
growth factor beta (TGFb) receptor, TGFbDNRII, with potential immunomodulating activity.
Upon administration, the TGFbDNRII-transduced autologous TILs recognize and kill tumor
cells. The expression of TGFbDNRII allows for the TILs to be resistant to TGF-b-mediated
inhibition of T cell proliferation and activation, which allows optimal TIL activity.
The immunosuppressant TGF-b is produced by tumor cells and plays a key role in the
repression of the immune system.;