" /> Autologous dnTGF-BRII-armored Anti-GPC3 CAR T-cells AZD5851 - CISMeF





Preferred Label : Autologous dnTGF-BRII-armored Anti-GPC3 CAR T-cells AZD5851;

NCIt synonyms : Autologous Armored GPC3 CAR-T Cells AZD5851; Autologous Anti-GPC3 CAR T Cells AZD5851; Autologous Anti-GPC3 CAR T-cells AZD5851; Autologous Anti-GPC3 CAR T-lymphocytes AZD5851; Autologous Anti-GPC3 CAR-T Cells AZD5851;

NCIt definition : A preparation of autologous T-lymphocytes that have been genetically modified to express a chimeric antigen receptor (CAR) specific for glypican-3 (GPC3) and the dominant negative (dn) form of transforming growth factor-beta (TGF-beta; TGFb) receptor 2 (dnTGF-BRII; dnTGFbR2), with potential immunomodulating and antineoplastic activities. Upon reintroduction into the patient, autologous dnTGF-BRII-armored anti-GPC3 CAR T-cells AZD5851 are directed to and induce selective toxicity in GPC3-expressing tumor cells. GPC3, a heparan sulfate proteoglycan and a member of the glypican family, is overexpressed on certain tumor cell types while minimally expressed on normal, healthy cells; GPC3 plays an important role in cellular proliferation and differentiation. The inclusion of dnTGF-BRII blocks the signaling of the immunosuppressive cytokine TGFb in the tumor microenvironment (TME) and makes the AZD5851 T-cells resistant to TGFb. TGFb negatively regulates T-cell proliferation and activation and plays a key role in tumor immune suppression.;

Molecule name : AZD-5851; AZD 5851;

NCI Metathesaurus CUI : CL1921230;

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02/05/2025


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