Autologous Engineered TCR-T Cells KSH01

Preferred Label : Autologous Engineered TCR-T Cells KSH01;

NCIt synonyms : Autologous TAA-specific TCR T-lymphocytes KSH01; Autologous TCR T-lymphocytes KSH01; TCR-T Cells KSH01; TCR-engineered T Cells KSH01;

NCIt definition : A preparation of autologous T-lymphocytes genetically modified to express a T-cell receptor (TCR) specific for an as of yet undisclosed tumor-associated antigen (TAA), with potential antineoplastic activity. Peripheral blood mononuclear cells (PBMCs) are isolated from a patient, transduced with a TCR specific for the TAA, and expanded ex-vivo. Upon reintroduction into the patient, the autologous engineered TCR-T cells KSH01 target and bind to tumor cells expressing the TAA, which may induce cell death in and halt the growth of cancer cells expressing the undisclosed TAA.;

Molecule name : KSH-01; KSH 01;

NCI Metathesaurus CUI : CL1912928;

Details

Origin ID

C192680;

UMLS CUI

C5785372;

Semantic type(s)
- Cell [UMLS semantic type]
chemical_or_drug_affects_cell_type_or_tissue
- Cytotoxic T-Lymphocyte [NCIt concept]
chemical_or_drug_has_mechanism_of_action
- Antigen Sensitization [NCIt concept]
chemical_or_drug_has_physiologic_effect
- Immunopotentiation [NCIt concept]
- T-Cell Activation [NCIt concept]
concept_is_in_subset
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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