NCIt definition : A preparation of autologous peripheral blood lymphocytes (PBLs) that have been transduced
with a lentiviral vector to express a chimeric antigen receptor (CAR) targeting the
tumor-associated antigen (TAA) CD19, with potential immunostimulating and antineoplastic
activities. Upon transfusion, the autologous UCD19 CAR T-cells recognize and bind
to CD19-expressing tumor cells, thereby selectively lysing CD19-expressing tumor cells.
CD19, a B-cell-specific cell surface antigen is overexpressed in B-cell lineage malignancies.;