Idecabtagene Vicleucel

Preferred Label : Idecabtagene Vicleucel;

NCIt synonyms : Anti-BCMA CAR T Cells BB2121; BCMA-specific CAR-expressing T Lymphocytes BB2121; Ide-cel; Anti-BCMA-CAR-transduced T Cells BB2121;

NCIt definition : A preparation of autologous peripheral blood T-lymphocytes (PBTLs) that have been genetically modified to express a chimeric antigen receptor (CAR) specific for the B-cell maturation antigen (BCMA), with potential immunostimulating and antineoplastic activities. Upon administration, idecabtagene vicleucel specifically recognizes and kills BCMA-expressing tumor cells. BCMA, a tumor-specific antigen and a receptor for both a proliferation-inducing ligand (APRIL) and B-cell activating factor (BAFF), is a member of the tumor necrosis factor receptor superfamily (TNFRSF) and plays a key role in plasma survival; it is found on the surfaces of plasma cells and overexpressed on malignant plasma cells.;

UNII : 8PX1X7UG4D;

Drug name : Abecma;

Molecule name : BB2121;

NCI Metathesaurus CUI : CL474124;

Codes from synonyms : 23426;

Details

Origin ID

C117729;

UMLS CUI

C3899973;

Currated CISMeF NLP mapping
- Idecabtagene vicleucel (substance) [SNOMED CT concept]
- idecabtagene vicleucel [MeSH Supplementary Concept]
- idecabtagene vicleucel [MeSH concept]
Semantic type(s)
- Cell [UMLS semantic type]
UMLS correspondences (same concept)
- Idecabtagene vicleucel (substance) [SNOMED CT concept]
- Product containing idecabtagene vicleucel (medicinal product) [SNOMED CT concept]
- idecabtagene vicleucel [MeSH Supplementary Concept]
- idecabtagene vicleucel [ATC Code]
Validated automatic mappings to BTNT
- idecabtagene vicleucel [ATC Code]
chemical_or_drug_affects_cell_type_or_tissue
- Cytotoxic T-Lymphocyte [NCIt concept]
chemical_or_drug_has_mechanism_of_action
- Antigen Sensitization [NCIt concept]
chemical_or_drug_has_physiologic_effect
- Immunopotentiation [NCIt concept]
- T-Cell Activation [NCIt concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- HemOnc Agent Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Tumor Necrosis Factor Receptor Superfamily Member 17 [NCIt concept]
is_component_of_chemotherapy_regimen
- Idecabtagene Vicleucel Regimen [NCIt concept]

Keyword's position in hierarchy(ies) :

Main resources

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