Triple-Class Refractory Multiple Myeloma

Preferred Label : Triple-Class Refractory Multiple Myeloma;

NCIt synonyms : Triple-Class Refractory Plasma Cell Myeloma;

NCIt definition : Multiple myeloma that is resistant to three classes of therapeutic agents, including proteasome inhibitors, immunomodulatory agents, and monoclonal antibodies.;

Neoplastic status : Malignant;

NCI Metathesaurus CUI : CL1647794;

Details

Origin ID

C178375;

UMLS CUI

C5554991;

Disease excludes abnormal cell
- Neoplastic T-Lymphocyte and Neoplastic Natural Killer Cell [NCIt concept]
Disease excludes normal cell origin
- Myeloid Cell [NCIt concept]
- Precursor B-Lymphoblast [NCIt concept]
Disease may have findings
- Bone Pain [NCIt concept]
- Hypercalcemia [NCIt concept]
- Monoclonal Gammopathy [NCIt concept]
- Osteolytic Metastatic Bone Lesion [NCIt concept]
- Pathologic Fracture [NCIt concept]
- Unfavorable Clinical Outcome [NCIt concept]
Has associated anatomic sites
- Hematopoietic System [NCIt concept]
- Hematopoietic and Lymphatic System [NCIt concept]
Manual BTNT mappings - CISMeF
- relapsed and refractory multiple myeloma, who have received at least three prior therapies, including an immunomodulatory agent, a proteasome inhibitor, and an anti-CD38 antibody and have demonstrated disease progression on the last therapy [Indication]
Semantic type(s)
- Neoplastic Process [UMLS semantic type]
concept_is_in_subset
- CTRP Disease Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
disease_excludes_finding
- Benign Cellular Infiltrate [NCIt concept]
- Localized Lesion [NCIt concept]
disease_has_abnormal_cell
- Abnormal Lymphocyte [NCIt concept]
- Malignant Cell [NCIt concept]
- Neoplastic B-Lymphocyte [NCIt concept]
- Neoplastic Cell [NCIt concept]
- Neoplastic Hematopoietic and Lymphoid Cell [NCIt concept]
- Neoplastic Lymphocyte [NCIt concept]
- Neoplastic Plasma Cell [NCIt concept]
disease_has_finding
- Aberrant Clonal Plasma Cell Population [NCIt concept]
- Malignant Cellular Infiltrate [NCIt concept]
- Neoplastic Plasma Cells Present in Bone Marrow [NCIt concept]
- Refractory Disease [NCIt concept]
- Triple-Class Exposed [NCIt concept]
disease_has_molecular_abnormality
- Clonal Immunoglobulin Gene Rearrangement [NCIt concept]
disease_has_normal_cell_origin
- B-Lymphocyte [NCIt concept]
- Bone Marrow-Homing Plasma Cell [NCIt concept]
- Hematopoietic and Lymphoid Cell [NCIt concept]
- Lymphocyte [NCIt concept]
- Mature B-Lymphocyte [NCIt concept]
- Plasma Cell [NCIt concept]
disease_has_normal_tissue_origin
- Hematopoietic and Lymphoid Tissue [NCIt concept]
- Lymphoid Tissue [NCIt concept]
disease_has_primary_anatomic_site
- Hematopoietic and Lymphatic System [NCIt concept]
- Lymphatic System [NCIt concept]
disease_mapped_to_chromosome
- Human Chromosome 11 [NCIt concept]
- Human Chromosome 13 [NCIt concept]
- Human Chromosome 14 [NCIt concept]
- Human Chromosome 15 [NCIt concept]
- Human Chromosome 19 [NCIt concept]
- Human Chromosome 3 [NCIt concept]
- Human Chromosome 5 [NCIt concept]
- Human Chromosome 7 [NCIt concept]
- Human Chromosome 8 [NCIt concept]
- Human Chromosome 9 [NCIt concept]
- Human Chromosome X [NCIt concept]
disease_may_have_abnormal_cell
- Anaplastic Plasma Cell [NCIt concept]
- Flame Cell [NCIt concept]
- Mott Cell [NCIt concept]
- Plasmablast [NCIt concept]
- Pleomorphic Plasma Cell [NCIt concept]
disease_may_have_associated_disease
- Anemia [NCIt concept]
- Renal Failure [NCIt concept]
disease_may_have_cytogenetic_abnormality
- Gain of Chromosome 11 [NCIt concept]
- Gain of Chromosome 15 [NCIt concept]
- Gain of Chromosome 19 [NCIt concept]
- Gain of Chromosome 3 [NCIt concept]
- Gain of Chromosome 5 [NCIt concept]
- Gain of Chromosome 7 [NCIt concept]
- Gain of Chromosome 9 [NCIt concept]
- Loss of Chromosome 14 [NCIt concept]
- Loss of Chromosome 8 [NCIt concept]
- Loss of Chromosome X [NCIt concept]
- Monosomy 13 [NCIt concept]
- del(13q14) [NCIt concept]
- t(11;14)(q13;q32) [NCIt concept]
disease_may_have_molecular_abnormality
- CCND1 Protein Overexpression [NCIt concept]

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