Recombinant Fowlpox-Tyrosinase Vaccine

Preferred Label : Recombinant Fowlpox-Tyrosinase Vaccine;

NCIt synonyms : rF-TYR vaccine; Tyrosinase-Fowl Pox; rF-TYR; Fowlpox-Tyrosinase Vaccine;

NCIt definition : A recombinant fowlpox virus vaccine with potential antineoplastic activity. Binding to the melanoma antigen tyrosinase, recombinant fowlpox-tyrosinase vaccine generates cellular immune responses against melanoma cells expressing the tyrosinase antigen; this effect is enhanced by the co-administration of interleukin 2 (IL-2). Fowlpox virus is an attractive vector because its genome is easy to manipulate and it is replication incompetent in mammalian cells.;

NSC code : 702141;

Details

Origin ID

C2807;

UMLS CUI

C1327884;

Semantic type(s)
- Immunologic Factor [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
chemical_or_drug_affects_abnormal_cell
- Melanoma Cell [NCIt concept]
chemical_or_drug_affects_cell_type_or_tissue
- Cytotoxic T-Lymphocyte [NCIt concept]
chemical_or_drug_has_mechanism_of_action
- Gene Regulation Process [NCIt concept]
chemical_or_drug_has_physiologic_effect
- Immunopotentiation [NCIt concept]
- T-Cell Activation [NCIt concept]
concept_is_in_subset
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Tyrosinase [NCIt concept]
is_component_of_chemotherapy_regimen
- Fowlpox-Tyrosinase Vaccine/Interleukin-2/Vaccinia-Tyrosinase Vaccine [NCIt concept]

Keyword's position in hierarchy(ies) :

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