HPV16 L2/E6/E7 Fusion Protein Vaccine TA-CIN

Preferred Label : HPV16 L2/E6/E7 Fusion Protein Vaccine TA-CIN;

NCIt synonyms : Tissue Antigen-Cervical Intraepithelial Neoplasia Vaccine;

NCIt definition : A recombinant human papillomavirus (HPV), genetically engineered fusion protein vaccine in which the three HPV16 viral proteins L2, E6 and E7 are fused together in a single tandem fusion protein (TA-CIN; HPV16 L2\\E6\\E7), with potential immunoprotective and antineoplastic properties. Upon administration, HPV16 L2\\E6\\E7 fusion protein vaccine TA-CIN may stimulate the immune system to generate HPV16 E6\\E7-specific CD4 and CD8 T-cell responses as well as the induction of L2-specific antibodies. In addition, this vaccine may prevent infection and the development of other HPV16-associated diseases. L2, a minor viral capsid protein, is able to induce a strong antibody response against certain HPV types.;

Molecule name : TA-CIN;

Details

Origin ID

C121648;

UMLS CUI

C4053587;

Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
chemical_or_drug_affects_cell_type_or_tissue
- Cytotoxic T-Lymphocyte [NCIt concept]
chemical_or_drug_has_mechanism_of_action
- Antigen Sensitization [NCIt concept]
chemical_or_drug_has_physiologic_effect
- Immunopotentiation [NCIt concept]
- T-Cell Activation [NCIt concept]
concept_is_in_subset
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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