PG13/LNc8 Retroviral Transduced Cloned T-Cells

Preferred Label : PG13/LNc8 Retroviral Transduced Cloned T-Cells;

NCIt synonyms : PG13-LNc8 Retroviral Transduced Cloned T-Cells;

NCIt definition : A preparation of T lymphocytes harvested from a patient with cancer and transduced with the PG13/Lnc8 retroviral vector, a clone of the LN vector that encodes the neomycin phosphotransferase gene. The modified T lymphocytes are cloned using an ex vivo technique and infused back into the patient, where they may elicit a host immune response against tumor cells. The neomycin phosphotransferase gene product has no direct therapeutic value; it serves as a molecular marker to monitor the presence and localization of the PG13/Lnc8-transduced T-lymphocytes in the host. (NCI04);

NSC code : 714743;

Details

Origin ID

C2790;

UMLS CUI

C1518789;

Semantic type(s)
- Cell [UMLS semantic type]
chemical_or_drug_affects_cell_type_or_tissue
- Cytotoxic T-Lymphocyte [NCIt concept]
chemical_or_drug_has_mechanism_of_action
- Antigen Sensitization [NCIt concept]
- Gene Regulation Process [NCIt concept]
chemical_or_drug_has_physiologic_effect
- Immunopotentiation [NCIt concept]
- Molecular Marker Activity [NCIt concept]
- T-Cell Activation [NCIt concept]

Keyword's position in hierarchy(ies) :

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