P53-Synthetic Long Peptides Vaccine

Preferred Label : P53-Synthetic Long Peptides Vaccine;

NCIt synonyms : P53-SLP (70-251) Vaccine; P53-Synthetic Long Peptides (70-251) Vaccine; P53-Synthetic Long Peptides 70-251 Vaccine;

NCIt definition : A peptide vaccine consisting of 10 synthetic long peptides (SLPs), 25-30 amino acids in size and derived from the middle portion of p53 (amino acids 70-251), mixed with the adjuvant Montanide ISA-51 with potential immunostimulatory and antitumor activities. Upon administration, p53 synthetic long peptide (70-251) vaccine may stimulate the host immune system to mount a cytotoxic T-cell lymphocyte (CTL) response against p53-expressing tumor cells. p53, a tumor associated antigen (TAA), may be overexpressed in variety of cancer cell types.;

Details

Origin ID

C82420;

UMLS CUI

C2826166;

Automatic exact mappings (from CISMeF team)
- p53 synthetic long peptide vaccine [MeSH Supplementary Concept]
- p53 synthetic long peptide vaccine [MeSH concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- p53 synthetic long peptide vaccine [MeSH Supplementary Concept]
chemical_or_drug_affects_cell_type_or_tissue
- Cytotoxic T-Lymphocyte [NCIt concept]
chemical_or_drug_has_mechanism_of_action
- Antigen Sensitization [NCIt concept]
chemical_or_drug_has_physiologic_effect
- Immunopotentiation [NCIt concept]
- T-Cell Activation [NCIt concept]
concept_is_in_subset
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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