Neldaleucel - CISMeF

Preferred Label : Neldaleucel;

NCIt synonyms : Multi-Tumor-Associated Antigen-Specific Autologous T Cells MT-601; Multi-antigen specific CD4 andCD8 Autologous T cells MT-601; Multi-TAA-specific Autologous T-cells MT-601; Autologous T-cells-targeting Six TAAs MT-601; Six TAAs-specific Autologous T-cells MT-601;

NCIt definition : A preparation of autologous, ex vivo-expanded, CD4- and CD8-positive T-lymphocytes specific for six tumor-associated antigens (TAAs), with potential immunomodulating and antineoplastic activities. Upon administration of neldaleucel, the T-cells target, bind to and induce selective toxicity in cancer cells overexpressing one or more of these six TAAs. By targeting more than one antigen, neldaleucel may be able to induce a better and more durable anti-tumor response due to its ability to overcome antigen loss.;

UNII : 78SU4N7MVG;

Molecule name : MT-601; MT 601;

NCI Metathesaurus CUI : CL1907474;

Details

Origin ID

C200467;

UMLS CUI

C5854545;

Semantic type(s)
- Cell [UMLS semantic type]
chemical_or_drug_affects_cell_type_or_tissue
- Cytotoxic T-Lymphocyte [NCIt concept]
chemical_or_drug_has_mechanism_of_action
- Antigen Sensitization [NCIt concept]
chemical_or_drug_has_physiologic_effect
- Immunopotentiation [NCIt concept]
- T-Cell Activation [NCIt concept]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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