" /> Eltrapuldencel-T - CISMeF





Preferred Label : Eltrapuldencel-T;

NCIt synonyms : DC-TC; Autologous Dendritic Cells Loaded with Irradiated Autologous Tumor Cells in Granulocyte-macrophage Colony-stimulating Factor; Autologous DCs Loaded with Irradiated Autologous Tumor Cells in GM-CSF; Melapuldencel-T;

NCIt definition : A therapeutic melanoma vaccine consisting of autologous dendritic cells (DCs) pulsed with antigens from lethally irradiated autologous tumor cells derived from a patient-specific, continuously proliferating and melanoma-initiating cell line and suspended in a solution containing the cytokine granulocyte-macrophage colony stimulating factor (GM-CSF), with potential immunostimulatory and antineoplastic activities. Upon subcutaneous administration, eltrapuldencel-T may stimulate the immune system to exert a cytotoxic T-lymphocyte (CTL) immune response against the patient's repertoire of melanoma-associated antigens, particularly tumor stem cell antigens, found in the irradiated autologous cancer cells. As an immunostimulant, GM-CSF enhances the activation of dendritic cells (DCs) and promotes antigen presentation to both B- and T-lymphocytes.;

UNII : M2LBQ7RN2X;

Molecule name : NBS-20;

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11/05/2024


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