" /> Autologous Anti-CD19 CAR T-cells 19(T2)28z1xx - CISMeF





Preferred Label : Autologous Anti-CD19 CAR T-cells 19(T2)28z1xx;

NCIt synonyms : Autologous CD19-Targeted CAR T-cells 19(T2)28z1xx; Autologous Anti-CD19 CAR-T Cells 19(T2)28z1xx; Autologous 19(T2)28z1xx CAR T-cells; 19(T2)28z1xx;

NCIt definition : A preparation of autologous T-lymphocytes that have been genetically modified to express a chimeric antigen receptor (CAR) targeting the tumor-associated antigen (TAA) CD19, and linked to the co-stimulatory intracellular signaling domains of CD28 and the zeta chain of the TCR/CD3 complex (CD3-zeta) (CD28zeta; CD28z), with potential immunostimulating and antineoplastic activities. Upon administration, the autologous anti-CD19 CAR T-cells 19(T2)28z1xx specifically recognize and bind to CD19-expressing tumor cells, resulting in specific T-cell-mediated tumor cell lysis. CD19 antigen is a B-cell specific cell surface antigen, which is expressed in all B-cell lineage malignancies and normal B-cells. CD28 and CD3zeta provide co-stimulatory activity and may enhance the cytotoxic effect and anti-tumor activity of the CAR T-cells. The 19(T2)28z1xx CAR T-cells include a 1928zeta mutant, 1xx, which contains one instead of all three immunoreceptor tyrosine-based activation motifs (iTAMs). This may help prevent counterproductive T-cell differentiation and exhaustion.;

NCI Metathesaurus CUI : CL1407373;

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15/05/2024


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