" /> Autologous Anti-ALPP CAR Retroviral Vector-transduced T Cells - CISMeF





Preferred Label : Autologous Anti-ALPP CAR Retroviral Vector-transduced T Cells;

NCIt synonyms : Autologous Anti-ALPP CAR-modified T-cells; Anti-ALPP CAR-expressing Retroviral Vector-transduced Autologous T Cells; Autologous Anti-ALPP CART-cells; Retroviral Vector-transduced Anti-PLAP CAR Autologous T-cells;

NCIt definition : A preparation of autologous T lymphocytes that have been transduced with a retroviral vector expressing a chimeric antigen receptor (CAR) targeting alkaline phosphatase, placental type (ALPP; placental alkaline phosphatase; PLAP), with potential immunostimulating and antineoplastic activities. Upon infusion back into the patient, autologous anti-ALPP CAR retroviral vector-transduced T cells target and bind to ALPP-expressing tumor cells, thereby inducing selective toxicity in ALPP-expressing tumor cells. ALPP, mainly expressed in placenta and testis, is overexpressed on certain tumor cell types, such as on a proportion of colorectal cancers while not expressed in any other normal tissues. It plays a key role in tumor cell proliferation.;

NCI Metathesaurus CUI : CL1661900;

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14/05/2024


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