Preferred Label : Autologous NY-ESO-1 TCR-targeted T Lymphocytes;
NCIt synonyms : NY-ESO-1 T Cell Receptor Genetically Modified Autologous T Cells;
NCIt definition : A preparation of human autologous T-lymphocytes that are transduced with a gene encoding
a T-cell receptor (TCR) specific for the cancer-testis antigen NY-ESO-1, with potential
immunostimulating and antineoplastic activities. Upon isolation, transduction, expansion
ex vivo, and reintroduction into the patient, the anti-NY-ESO-1 TCR-transduced autologous
T-cells recognize and bind to NY-ESO-1-overexpressing tumor cells. This may result
in a specific cytotoxic T-lymphocyte (CTL)-mediated killing of NY-ESO-1-positive tumor
cells. NY-ESO-1, a tumor-associated antigen (TAA), is found in normal testis and on
the surface of various tumor cell types, and is not, or is minimally, expressed in
normal, healthy cells.;
NCI Metathesaurus CUI : CL550794;
Origin ID : C148150;
UMLS CUI : C4727621;
Semantic type(s)
- Cell [UMLS semantic type]
- chemical_or_drug_affects_cell_type_or_tissue
- chemical_or_drug_has_mechanism_of_action
- chemical_or_drug_has_physiologic_effect
- concept_is_in_subset
- has_target
