Recombinant Vaccinia-MUC1-B7 Vaccine

Preferred Label : Recombinant Vaccinia-MUC1-B7 Vaccine;

NCIt synonyms : Recombinant Vaccinia-MUC1-B7.1; MUC1-B7-Vaccinia Vaccine; rV-MUC1-B7.1; Recombinant Vaccinia-MUC-1 B7;

NCIt definition : An admixture of recombinant vaccinia virus encoding MUC-1 and recombinant vaccinia virus encoding the murine T-cell co-stimulatory molecule B7.1. MUC-1 is a glycosylated mucin that is overexpressed in breast, lung, pancreatic, prostate, stomach, colon, and ovarian carcinomas. Vaccination with MUC-1 in combination with B7.1 may enhance the cytotoxic T cell (CTL) immune response to tumors expressing MUC-1, compared to vaccination with MUC-1 alone. (NCI04);

NSC code : 669024;

Details

Origin ID

C29409;

UMLS CUI

C1514792;

Semantic type(s)
- Immunologic Factor [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
chemical_or_drug_affects_cell_type_or_tissue
- Cytotoxic T-Lymphocyte [NCIt concept]
chemical_or_drug_has_mechanism_of_action
- Antigen Sensitization [NCIt concept]
chemical_or_drug_has_physiologic_effect
- Immunopotentiation [NCIt concept]
- T-Cell Activation [NCIt concept]

Keyword's position in hierarchy(ies) :

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