Preferred Label : iC9-GD2-CAR-CD28-OX40-expressing Autologous NKT Cells;
NCIt synonyms : GINAKIT Cells; GD2-CAR NKT Cells; GINAKIT-cells; GD2-CAR-expressing Autologous Natural Killer T-Cells; iC9-GD2.CD28.OX40.zeta Natural Killer T Cells;
NCIt definition : A preparation of autologous interleukin-15 (IL-15)-expressing natural killer T-cells
(NKT) transduced with a retroviral vector encoding a chimeric antigen receptor (CAR)
derived from the antibody 14G2a that recognizes disialoganglioside GD2 (GD2-CAR) that
is coupled to the co-stimulatory domains of CD28 and OX40 (CD134), and to the zeta
chain of the TCR/CD3 complex (CD3-zeta), and linked to the suicide gene inducible
caspase 9 (iCasp9 or iC9), with potential immunomodulating and antineoplastic activities.
Upon transfusion, the iC9-GD2-CAR-CD28-OX40-expressing autologous NKT cells recognize,
bind to and induce selective cytotoxicity in GD2-expressing tumor cells. The tumor-associated
antigen (TAA) GD2 is overexpressed on the surface of neuroblastoma cells and by other
neuroectoderm-derived neoplasms, while it is minimally expressed on normal, healthy
cells. The iCasp9 safety switch consists of a full-length caspase 9, including its
caspase recruitment domain, linked to a human FK506 drug-binding domain with an F36V
mutation (FKBP12-F36V). If the administered NKT cells lead to unacceptable side effects,
the chemical homodimerizer AP1903, which binds to the FKBP12-F36V drug-binding domain,
activates caspase 9, and results in apoptosis of the administered NKT cells, can be
administered.;
NCI Metathesaurus CUI : CL550809;
Origin ID : C148135;
UMLS CUI : C4724838;
Semantic type(s)
- Cell [UMLS semantic type]
- chemical_or_drug_affects_cell_type_or_tissue
- chemical_or_drug_has_mechanism_of_action
- chemical_or_drug_has_physiologic_effect
- concept_is_in_subset
