Autologous Anti-FcRL5 CAR-T Cells

Preferred Label : Autologous Anti-FcRL5 CAR-T Cells;

NCIt synonyms : Autologous Anti-FcRL5 CAR T Cells; Anti-FcRL5 CAR-modified T-cells;

NCIt definition : A preparation of autologous T-lymphocytes engineered to express a chimeric antigen receptor (CAR) targeting Fc receptor-like protein 5 (FcRL5; Fc receptor-homolog 5; FcRH5), with potential antineoplastic activity. Upon administration, autologous anti-FcRL5 CAR-T cells recognize and kill FcRL5-expressing tumor cells. FcRL5, an immune receptor translocation-associated protein/Fc receptor homolog (IRTA/FcRH) family member and a B-cell lineage marker, is overexpressed in multiple myeloma.;

NCI Metathesaurus CUI : CL1928598;

Details

Origin ID

C206266;

chemical_or_drug_affects_cell_type_or_tissue
- Cytotoxic T-Lymphocyte [NCIt concept]
chemical_or_drug_has_mechanism_of_action
- Antigen Sensitization [NCIt concept]
chemical_or_drug_has_physiologic_effect
- Immunopotentiation [NCIt concept]
- T-Cell Activation [NCIt concept]
concept_is_in_subset
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Fc Receptor-Like Protein 5 [NCIt concept]

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