Anti-gp100 TCR Retroviral Vector-Transduced Autologous PBL

Preferred Label : Anti-gp100 TCR Retroviral Vector-Transduced Autologous PBL;

NCIt synonyms : GCsamAPB (Anti-gp100 TCR) Retroviral Vector-Transduced Autologous PBL;

NCIt definition : Human peripheral blood lymphocytes (PBL) isolated from a melanoma patient and were engineered to react with the melanoma antigen glycoprotein 100 (gp100). These PBL are transduced with a retroviral pGCsam vector encoding T-cell receptors specific for gp100, grown in culture, and then transferred back to the patient. These genetically modified PBL may recognize and halt the growth of gp100-expressing melanoma cells.;

NSC code : 729277;

Details

Origin ID

C38136;

UMLS CUI

C1515996;

Semantic type(s)
- Cell [UMLS semantic type]
chemical_or_drug_affects_cell_type_or_tissue
- Cytotoxic T-Lymphocyte [NCIt concept]
chemical_or_drug_has_mechanism_of_action
- Antigen Sensitization [NCIt concept]
chemical_or_drug_has_physiologic_effect
- Immunopotentiation [NCIt concept]
- T-Cell Activation [NCIt concept]
has_target
- Melanocyte Protein PMEL [NCIt concept]

Keyword's position in hierarchy(ies) :

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