Preferred Label : Autologous CD171-specific CAR-CD28 zeta-4-1-BB-EGFRt-expressing T Lymphocytes;
NCIt synonyms : CD171 CAR T Cells; CE7R CAR T Cells;
NCIt definition : A preparation of genetically modified autologous human T-lymphocytes transduced with
a lentiviral vector expressing a chimeric antigen receptor (CAR) specific for the
L1 cell adhesion molecule (L1-CAM/CD171) antigen, and the co-stimulatory signaling
domains CD28, 4-1BB (CD137) and CD3 zeta, and a truncated form of the human epidermal
growth factor receptor (EGFRt), with potential immunostimulating and antineoplastic
activities. Upon re-infusion into the patient, the autologous L1-CAM-specific CAR-CD28
zeta-4-1-BB-EGFRt-expressing T-lymphocytes are directed to and induce selective toxicity
in L1-CAM-expressing tumor cells. L1-CAM, a neuronal cell adhesion molecule and member
of the L1 protein family, plays a key role in the development of the nervous system;
it is overexpressed in various tumor cell types and is associated with increased chemoresistance,
tumor progression, migration and metastasis. Devoid of both ligand-binding domains
and tyrosine kinase activity, EGFRt facilitates both the detection of the administered
T-cells in vivo and the elimination of the modified T-cells following a cetuximab-induced
antibody-dependent cellular cytotoxicity (ADCC) response. The co-stimulatory signaling
domains enhance both proliferation of T-cells and antitumor activity.;
Origin ID : C119746;
UMLS CUI : C3900004;
Semantic type(s)
- Cell [UMLS semantic type]
- chemical_or_drug_affects_cell_type_or_tissue
- chemical_or_drug_has_mechanism_of_action
- chemical_or_drug_has_physiologic_effect
- concept_is_in_subset
- has_target
