HPV 16/18 E6/E7 DNA Vaccine pBI-11

Preferred Label : HPV 16/18 E6/E7 DNA Vaccine pBI-11;

NCIt synonyms : E6/E7 DNA Vaccine pBI-11; DNA Vaccine pBI-11;

NCIt definition : A therapeutic codon-optimized DNA vaccine encoding for the E6 and E7 proteins of human papillomavirus (HPV) subtypes 16 and 18, with potential immunostimulating and antineoplastic activities. Upon administration, the HPV 16/18 E6/E7 DNA vaccine pBI-11 expresses the HPV 16/18 E6/E7 fusion protein which may elicit a specific cytotoxic T-lymphocyte (CTL) response against cancer cells expressing the HPV 16/18 E6 and E7 oncoproteins, resulting in tumor cell lysis. HPV type 16 and 18 are the most common HPV types involved in cervical carcinogenesis. Codon optimization of the HPV16/18 E6/E7 genes in pBI-11 improves fusion protein expression.;

Molecule name : pBI-11; pBI 11;

NCI Metathesaurus CUI : CL1913812;

Details

Origin ID

C198007;

UMLS CUI

C5786712;

Semantic type(s)
- Immunologic Factor [UMLS semantic type]
- Nucleic Acid, Nucleoside, or Nucleotide [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
chemical_or_drug_affects_cell_type_or_tissue
- Cytotoxic T-Lymphocyte [NCIt concept]
chemical_or_drug_has_mechanism_of_action
- Antigen Sensitization [NCIt concept]
chemical_or_drug_has_physiologic_effect
- Immunopotentiation [NCIt concept]
- T-Cell Activation [NCIt concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Protein E6, Human Papillomavirus Type 16 [NCIt concept]
- Protein E7, Human Papillomavirus Type 16 [NCIt concept]

Keyword's position in hierarchy(ies) :

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