Autologous ROR2-targeted CAR T-cells CCT301-59 - CISMeF
Autologous ROR2-targeted CAR T-cells CCT301-59NCIt concept
Preferred Label : Autologous ROR2-targeted CAR T-cells CCT301-59;
NCIt synonyms : Autologous CAR T-cells Targeting ROR2 CCT301-59; Autologous CCT301-59 CAR T Cells; Autologous Anti-ROR2 CAR T Cells CCT301-59;
NCIt definition : A preparation of genetically modified autologous T-lymphocytes transduced with a lentiviral
vector to express a chimeric antigen receptor (CAR) targeting the receptor tyrosine
kinase-like orphan receptor 2 (ROR2), with potential immunomodulatory and antineoplastic
activities. After isolation, transduction, and expansion in culture, CCT301-59 cells
are reintroduced into the patient and are activated within the tumor microenvironment
(TME) using proprietary Conditionally Active Biologic (CAB) technology. Upon activation,
CAB antibodies bind to a proprietary T-cell signaling domain, promoting T-cell recognition
and killing of ROR2-expressing tumor cells. ROR2 is involved in Wnt signal transduction
and is involved in tumorigenesis and progression. ROR2 expression is upregulated in
certain tumor types and high levels of ROR2 expression often correlates with poor
prognosis.;