Autologous Anti-FGFR4 CAR T-cells

Preferred Label : Autologous Anti-FGFR4 CAR T-cells;

NCIt synonyms : Autologous Anti-FGFR4 CAR-T Cells; Autologous FGFR4-CAR T Cells;

NCIt definition : A preparation of autologous T-lymphocytes that have been genetically engineered to express a chimeric antigen receptor (CAR) targeting human fibroblast growth factor receptor 4 (FGFR4), with potential immunostimulating and antineoplastic activities. Upon administration, autologous anti-FGFR4 CAR T-cells recognize and induce selective toxicity in FGFR4-expressing tumor cells. FGFR4, a receptor tyrosine kinase, is involved in angiogenesis and in the proliferation, differentiation, and survival of tumor cells.;

Détails

Origin ID

C215004;

chemical_or_drug_affects_cell_type_or_tissue
- Cytotoxic T-Lymphocyte [NCIt concept]
chemical_or_drug_has_mechanism_of_action
- Antigen Sensitization [NCIt concept]
chemical_or_drug_has_physiologic_effect
- Immunopotentiation [NCIt concept]
- T-Cell Activation [NCIt concept]
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- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
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- Fibroblast Growth Factor Receptor 4 [NCIt concept]

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