" /> Autologous CLL1-CD33 Compound CAR T Cells - CISMeF





Preferred Label : Autologous CLL1-CD33 Compound CAR T Cells;

NCIt synonyms : Autologous CLL1-CD33 cCAR T-lymphocytes; Autologous CLL1-CD33 cCAR; Autologous CLL1-CD33 cCAR T Cells; Autologous Anti-CLL1/Anti-CD33 CARs-expressing T-lymphocytes;

NCIt definition : Autologous T-lymphocytes transduced with a lentiviral vector expressing a compound chimeric antigen receptor (cCAR) containing two CARs, one specific for the CD33 antigen and one specific for the C-type-lectin-like molecule-1 (CLL1; C-type lectin domain family 12 member A; CLEC12A), with potential immunomodulating and antineoplastic activities. Upon administration, the CD33/CLL1-specific CARs lentiviral vector-transduced autologous T-lymphocytes, expressing both the anti-CD33 CAR and the anti-CLL1 CAR on their surfaces, specifically and simultaneously target and bind to CD33- and CLL1-expressing tumor cells, with their anti-CD33 CAR and their anti-CLL1 CAR, respectively. This induces selective toxicity in tumor cells that express the CD33 antigen and the CLL1 antigen. CD33 is expressed on normal non-pluripotent hematopoietic stem cells and is overexpressed on myeloid leukemia cells. CLL1, a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily, is overexpressed in leukemic stem cells (LSCs) and plays an important role in disease progression and relapse for myeloid malignancies.;

NCI Metathesaurus CUI : CL937014;

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15/05/2024


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