Microparticle-encapsulated CYP1B1-encoding DNA Vaccine ZYC300 - CISMeF
Microparticle-encapsulated CYP1B1-encoding DNA Vaccine ZYC300NCIt concept
Preferred Label : Microparticle-encapsulated CYP1B1-encoding DNA Vaccine ZYC300;
NCIt definition : A formulation of a plasmid DNA encoding an inactivated form of the carcinogen activator
cytochrome P450 1B1 (CYP1B1) encapsulated in biodegradable poly-DL-lactide-coglycolide
microparticles with potential antineoplastic activity. CYP1B1, an extrahepatic monooxygenase
of the cytochrome P450 family, is overexpressed in many cancers with only restricted
expression in normal tissues. Vaccination with ZYC300 may stimulate the immune system
to elicit a cytotoxic T lymphocyte (CTL) response against the tumor associated antigen
CYP1B1, thereby causing lysis of tumor cells expressing CYP1B1.;