Autologous IL-7Ra-expressing Tris-CAR T-cells

Preferred Label : Autologous IL-7Ra-expressing Tris-CAR T-cells;

NCIt synonyms : Autologous Inverse-correlated Dual-target Truncated IL7Ra-modified CAR-expressing T-lymphocytes; Autologous Tris-CAR-T Cells;

NCIt definition : A preparation of autologous T-lymphocytes that have been genetically modified and lentivirally transduced to express a dual-target chimeric antigen receptor (CAR) and a truncated form of the cytokine receptor interleukin-7 (IL-7) receptor alpha (IL-7Ra), with potential immunostimulating and antineoplastic activities. Upon administration, autologous IL-7Ra-expressing Tris-CAR T-cells target and bind to tumor cells expressing the targets, thereby inducing selective toxicity in these tumor cells. In addition, as IL-7/IL-7Ra-mediated signaling promotes the proliferation and survival of T-cells, these tumor re-directed T-cells may show enhanced expansion, survival and cytotoxicity.;

NCI Metathesaurus CUI : CL1912845;

Details

Origin ID

C192816;

UMLS CUI

C5787281;

Semantic type(s)
- Cell [UMLS semantic type]
chemical_or_drug_affects_cell_type_or_tissue
- Cytotoxic T-Lymphocyte [NCIt concept]
chemical_or_drug_has_mechanism_of_action
- Antigen Sensitization [NCIt concept]
chemical_or_drug_has_physiologic_effect
- Immunopotentiation [NCIt concept]
- T-Cell Activation [NCIt concept]
concept_is_in_subset
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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