Autologous Anti-GPC3 CAR T-lymphocytes JWAT204

Preferred Label : Autologous Anti-GPC3 CAR T-lymphocytes JWAT204;

NCIt synonyms : Autologous CAR-GPC3 T Cells JWAT204; Autologous GPC3-directed CAR-T Cells JWAT204; Autologous Anti-GPC3 CAR T-cells JWAT204; Autologous Anti-GPC3 CAR T Cells JWAT204;

NCIt definition : A preparation of autologous T-lymphocytes that have been genetically modified to express a chimeric antigen receptor (CAR) specific for glypican-3 (GPC3), with potential immunostimulating and antineoplastic activities. Upon administration, autologous anti-GPC3 CAR T-lymphocytes JWAT204 specifically target and bind to GPC3-expressing tumor cells, resulting in tumor cell lysis. GPC3, a heparan sulfate proteoglycan and a member of the glypican family, is overexpressed on certain tumor cell types while minimally expressed in normal, healthy cells; GPC3 plays an important role in cellular proliferation and differentiation.;

Molecule name : JWAT 204; JWAT-204;

NCI Metathesaurus CUI : CL1926430;

Details

Origin ID

C204171;

UMLS CUI

C5908039;

Semantic type(s)
- Pharmacologic Substance [UMLS semantic type]
chemical_or_drug_affects_cell_type_or_tissue
- Cytotoxic T-Lymphocyte [NCIt concept]
chemical_or_drug_has_mechanism_of_action
- Antigen Sensitization [NCIt concept]
chemical_or_drug_has_physiologic_effect
- Immunopotentiation [NCIt concept]
- T-Cell Activation [NCIt concept]
concept_is_in_subset
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Glypican-3 [NCIt concept]

Keyword's position in hierarchy(ies) :

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