Autologous Tolerogenic Proinsulin Peptide-loaded Dendritic Cells PIpepTolDC

Preferred Label : Autologous Tolerogenic Proinsulin Peptide-loaded Dendritic Cells PIpepTolDC;

NCIt synonyms : Proinsulin-loaded Tolerogenic DCs PIpepTolDC; Tolerogenic DC Vaccine PIpepTolDC; Autologous Tolerogenic DC with Proinsulin Peptide PIpepTolDC; Autologous Tolerogenic PIpep-loaded Dendritic Cells PIpepTolDC; PIpepTolDC Vaccine;

NCIt definition : A vaccine composed of autologous tolerogenic dendritic cells (DCs) loaded with the beta cell protein proinsulin peptide (PIpep), C19-A3, with potential immunosuppressive and immune-regulating activities. Upon intradermal administration, the autologous tolerogenic PIpep-loaded DCs may induce proinsulin-specific regulatory T-cells (Tregs). This may suppress the autoimmune destruction of the insulin-producing beta cells, thereby protecting the beta cells.;

Molecule name : PIpepTolDC;

NCI Metathesaurus CUI : CL1642410;

Details

Origin ID

C176573;

UMLS CUI

C5447312;

Semantic type(s)
- Cell [UMLS semantic type]
chemical_or_drug_affects_cell_type_or_tissue
- Cytotoxic T-Lymphocyte [NCIt concept]
chemical_or_drug_has_mechanism_of_action
- Antigen Sensitization [NCIt concept]
chemical_or_drug_has_physiologic_effect
- Immunopotentiation [NCIt concept]
- T-Cell Activation [NCIt concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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