Ciltacabtagene Autoleucel

Preferred Label : Ciltacabtagene Autoleucel;

NCIt synonyms : Autologous Anti-BCMA CAR-T Cells JNJ-68284528; Autologous Bi-epitope CAR T-cells JNJ-68284528; LCAR-B38M-transduced CAR-T Cells JNJ-68284528; Autologous Bi-epitope BCMA-targeted CAR T-cells JNJ-68284528; Cilta-cel;

NCIt definition : A preparation of autologous T-lymphocytes that are transduced, ex vivo, with LCAR-B38M, a lentiviral vector expressing a chimeric antigen receptor (CAR) containing two bispecific anti-B-cell maturation antigen (BCMA) variable fragments of llama heavy-chain murine antibodies fused to the signaling domain of 4-1BB (CD137), with potential immunostimulating and antineoplastic activities. The antigen-binding region of the CAR is a non-scFv structure targeting two distinct regions of BCMA. Upon intravenous administration back into the patient, ciltacabtagene autoleucel are directed to cells expressing BCMA, bind to two different epitopes on BCMA and induce selective toxicity in BCMA-expressing tumor cells. BCMA, a tumor-associated antigen (TAA) and a receptor for both a proliferation-inducing ligand (APRIL) and B-cell activating factor (BAFF), is a member of the tumor necrosis factor receptor superfamily (TNFRSF) and plays a key role in plasma cell survival. BCMA is overexpressed on malignant plasma cells.;

UNII : 0L1F17908Q;

Drug name : CARVYKTI;

Molecule name : LCAR-B38M; JNJ-68284528;

NCI Metathesaurus CUI : CL551044;

Codes from synonyms : 51229;

Details

Origin ID

C148498;

UMLS CUI

C4727630;

Semantic type(s)
- Cell [UMLS semantic type]
UMLS correspondences (same concept)
- ciltacabtagene autoleucel [ATC Code]
Validated automatic mappings to BTNT
- ciltacabtagene autoleucel [ATC Code]
chemical_or_drug_affects_cell_type_or_tissue
- Cytotoxic T-Lymphocyte [NCIt concept]
chemical_or_drug_has_mechanism_of_action
- Antigen Sensitization [NCIt concept]
chemical_or_drug_has_physiologic_effect
- Immunopotentiation [NCIt concept]
- T-Cell Activation [NCIt concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- HemOnc Agent Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Tumor Necrosis Factor Receptor Superfamily Member 17 [NCIt concept]
is_component_of_chemotherapy_regimen
- Ciltacabtagene Autoleucel Regimen [NCIt concept]

Keyword's position in hierarchy(ies) :

Main resources

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