Preferred Label : Autologous NKG2D CAR T-cells CYAD-02;
NCIt synonyms : Autologous NKG2D CAR-T Cells CYAD-02; Autologous NKG2D CAR T-lymphocytes CYAD-02; Autologous NKG2D-based CAR T-cells CYAD-02;
NCIt definition : A preparation of autologous T-lymphocytes that have been genetically modified and
transduced with a retroviral vector to co-express a chimeric antigen receptor (CAR)
encoding human natural-killer group 2, member D receptor protein (NKG2D or KLRK1)
with a short hairpin RNA (shRNA) targeting MHC class I chain-related protein A (MICA)
and MICB, with potential immunostimulating and antineoplastic activities. Upon infusion
back into the patient, autologous NKG2D CAR T-cells CYAD-02 specifically recognize
and bind to tumor cells expressing NKG2D ligands, resulting in the lysis of NKG2D
ligand-expressing tumor cells. In addition, CYAD-02 targets, binds to and kills NKG2D
ligand expressing tumor-associated endothelial cells in the neovasculature and immunosuppressive
cells, such as regulatory T-cells (Tregs) and myeloid-derived suppressor cells (MDSCs)
in the tumor microenvironment (TME) that express NKG2D ligands. It also activates
macrophages within the TME. Ligands for NKG2D, such as MICA, MICB, and members of
the UL16-binding proteins (ULBP)/retinoic acid early transcript 1 (RAET1) family,
are overexpressed on infected cells and most cancer cell types, but are not expressed
on most normal, healthy cells. NKG2D, a dimeric, type II transmembrane protein expressed
on human natural killer (NK) and certain T-cells, in association with the natural
adaptive protein DAP10, promotes the elimination of NKG2D ligand-expressing cells.
The shRNA downregulates the expression of MICA and MICB on the CAR-T cells, which
increases in-vitro cell expansion. This may enhance their persistence and increase
anti-tumor activity.;
Molecule name : CYAD 02; CYAD-02;
NCI Metathesaurus CUI : CL1407525;
Origin ID : C173710;
UMLS CUI : C5418020;
Semantic type(s)
- Cell [UMLS semantic type]
- chemical_or_drug_affects_cell_type_or_tissue
- chemical_or_drug_has_mechanism_of_action
- chemical_or_drug_has_physiologic_effect
- concept_is_in_subset
- has_target
