MHC Class I Polypeptide-Related Sequence A

Preferred Label : MHC Class I Polypeptide-Related Sequence A;

NCIt synonyms : Stress Inducible Class I Homolog; MIC-A; MICA;

NCIt definition : MHC class I polypeptide-related sequence A (383 aa, 43 kDa) is encoded by the human MICA gene. This protein plays a role in the negative regulation of natural killer cells.;

NCIt note : MHC class I polypeptide-related sequence A appears to have no role in antigen presentation. The shedding of MHC class I polypeptide-related sequence A-related antibodies and ligands is involved in the progression from monoclonal gammopathy of undetermined significance (MGUS) to multiple myeloma.;

Details

Origin ID

C126961;

UMLS CUI

C1448848;

Automatic exact mappings (from CISMeF team)
- MHC class I polypeptide-related sequence A [HGNC gene]
- Major histocompatibility complex class I chain-related gene a [OMIM gene]
- Mica [DeCS]
- Mica [DeCS]
- Mica (substance) [SNOMED CT concept]
- mica [Substance BNPC]
- mica [MeSH concept]
- mica [MeSH Supplementary Concept]
- mica [SNOMED Notion]
OMIM relation
- Major histocompatibility complex class I chain-related gene a [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
UMLS correspondences (same concept)
- MICA protein, human [MeSH concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Immunoprotein Gene [NCIt concept]
- MICA Gene [NCIt concept]
gene_product_has_associated_anatomy
- Plasma Membrane [NCIt concept]
gene_product_has_chemical_classification
- Transmembrane Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Transmembrane Domain [NCIt concept]
gene_product_is_element_in_pathway
- Natural Killer Cell-Mediated Cytotoxicity Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Antigen Binding [NCIt concept]
- Antimicrobial Effect [NCIt concept]
- Immune System Process [NCIt concept]
- NK Cell Activation [NCIt concept]
- Receptor Binding [NCIt concept]
- T-Cell Activation [NCIt concept]
is_target
- Anti-MICA/MICB Monoclonal Antibody CLN-619 [NCIt concept]
- Autologous Anti-NKG2DL/Anti-CLDN18.2 Bispecific CAR-T Cells KD-496 [NCIt concept]
- Autologous NKG2D CAR T Cells KD-025 [NCIt concept]
- Autologous NKG2D CAR T-cells CYAD-02 [NCIt concept]
- Autologous NKG2D CAR-CD3zeta-DAP10-expressing T-Lymphocytes CYAD-01 [NCIt concept]

Keyword's position in hierarchy(ies) :

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