Preferred Label : Autologous NKG2D CAR T Cells KD-025;
NCIt synonyms : NKG2D-specific CAR-T Cells KD-025; Autologous CAR-T Cells KD-025;
NCIt definition : A preparation of autologous T-lymphocytes that have been genetically modified to express
a chimeric antigen receptor (CAR) encoding human natural-killer group 2, member D
receptor protein (NKG2D or KLRK1) coupled to the co-immunostimulatory signaling domain
4-1BB, normally expressed on T-cells, and linked to the intracellular CD3 zeta domain
(CD3z), which is needed for TCR signaling, with potential immunostimulating and antineoplastic
activities. Upon infusion back into the patient, autologous NKG2D CAR T cells KD-025
specifically recognize and bind to tumor cells expressing NKG2D ligands (NKG2DLs),
resulting in cytokine secretion and lysis of NKG2D ligand-expressing tumor cells.
NKG2DLs, such as MICA, MICB, and members of the UL16-binding proteins (ULBP)/retinoic
acid early transcript 1 (RAET1) family, are overexpressed on a variety of cancer cell
types, but are not expressed on most normal, healthy cells.;
Molecule name : KD 025; KD-025;
NCI Metathesaurus CUI : CL1662166;
Origin ID : C179622;
UMLS CUI : C5552872;
Semantic type(s)
- Cell [UMLS semantic type]
- chemical_or_drug_affects_cell_type_or_tissue
- chemical_or_drug_has_mechanism_of_action
- chemical_or_drug_has_physiologic_effect
- concept_is_in_subset
- has_target
