MHC Class I Polypeptide-Related Sequence B

Preferred Label : MHC Class I Polypeptide-Related Sequence B;

NCIt synonyms : MIC-B;

NCIt definition : MHC class I polypeptide-related sequence B (383 aa, 43 kDa) is encoded by the human MICB gene. This protein plays a role in activation of cytolysis by natural killer cells, CD8 alpha-beta T cells, and gamma-delta T cells.;

Details

Origin ID

C104650;

UMLS CUI

C1448849;

Automatic exact mappings (from CISMeF team)
- MHC class I polypeptide-related sequence B [HGNC gene]
- Major histocompatibility complex class I chain-related gene b [OMIM gene]
OMIM relation
- Major histocompatibility complex class I chain-related gene b [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
UMLS correspondences (same concept)
- MICB protein, human [MeSH concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Immunoprotein Gene [NCIt concept]
- MICB Gene [NCIt concept]
gene_product_has_associated_anatomy
- Plasma Membrane [NCIt concept]
gene_product_has_chemical_classification
- Transmembrane Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Transmembrane Domain [NCIt concept]
gene_product_is_element_in_pathway
- Natural Killer Cell-Mediated Cytotoxicity Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Antigen Binding [NCIt concept]
- Immune System Process [NCIt concept]
- NK Cell Activation [NCIt concept]
- Receptor Binding [NCIt concept]
- T-Cell Activation [NCIt concept]
is_target
- Allogeneic iPSC-derived Anti-MICA/B CAR/CD16/IL-15RF-expressing CD38-eliminated NK Cells FT536 [NCIt concept]
- Anti-MICA/MICB Monoclonal Antibody CLN-619 [NCIt concept]
- Autologous Anti-NKG2DL/Anti-CLDN18.2 Bispecific CAR-T Cells KD-496 [NCIt concept]
- Autologous NKG2D CAR T Cells KD-025 [NCIt concept]
- Autologous NKG2D CAR T-cells CYAD-02 [NCIt concept]
- Autologous NKG2D CAR-CD3zeta-DAP10-expressing T-Lymphocytes CYAD-01 [NCIt concept]

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