NCIt definition : A human immunoglobulin G1 (IgG1) monoclonal antibody directed against the natural-killer
group 2, member D receptor protein (NKG2D or KLRK1) ligands MHC class I polypeptide-related
sequence A (MICA) and B (MICB), with potential immunostimulating and antineoplastic
activities. Upon administration, isuventatug targets and binds to the alpha3 domain
of MICA and MICB, and prevents the cleavage of MICA and MICB from the cell surface
of tumor cells by proteases in the tumor microenvironment (TME). This enhances the
binding of NKG2D-expressing immune cells, including natural killer (NK) cells and
subset of T-cells, to MICA- and MICB-expressing tumor cells, which leads to the activation
of NK cells and the lysis of tumor cells. CLN-619 also enhances antitumor response
through antibody-dependent cell-mediated cytotoxicity (ADCC). MICA and MICB are stress-induced
NKG2D ligands overexpressed on infected cells and many cancer cell types, but are
not expressed on most normal, healthy cells. The shedding of MICA and MICB from tumor
cell surface allows the tumor cells to evade NKG2D-expressing immune cells.;
Semantic type(s)