Preferred Label : Anti-MICA/MICB Monoclonal Antibody DM919;
NCIt synonyms : Anti-MICA/B Antibody DM919;
NCIt definition : A humanized immunoglobulin G1 (IgG1) monoclonal antibody directed against the natural-killer
group 2, member D receptor protein (NKG2D or KLRK1) ligands MHC class I polypeptide-related
sequence A (MICA) and B (MICB), with potential immunostimulating and antineoplastic
activities. Upon administration, anti-MICA/MICB monoclonal antibody DM919 targets
and binds to both MICA and MICB, and prevents the cleavage of MICA and MICB from the
cell surface of tumor cells by proteases in the tumor microenvironment (TME), thereby
stabilizing expression of surface MICA/B. This enhances the binding of NKG2D-expressing
immune cells, including natural killer (NK) cells and T-cells, to MICA- and MICB-expressing
tumor cells, which leads to the activation of NK cells and the NK-mediated lysis of
tumor cells. In addition, DM919 enhances antitumor response through antibody-dependent
cell-mediated cytotoxicity (ADCC). MICA and MICB are stress-induced NKG2D ligands
overexpressed on infected cells and many cancer cell types, but are not expressed
on most normal, healthy cells. The shedding of MICA and MICB from tumor cell surface
allows the tumor cells to evade NKG2D-expressing immune cells.;
Molecule name : DM 919; DM-919;
Origin ID : C212062;
chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
- has_target
