NCIt definition : Human autologous lymphocytes transduced with a retroviral vector encoding a T-cell
receptor (TCR) specific for the cancer/testis antigen NY-ESO-1, with potential antineoplastic
activity. Upon isolation, transduction, expansion ex vivo, and reintroduction into
the patient, the autologous T-lymphocytes expressing NY-ESO-1-C259-specific enhanced
T-cell receptors bind to NY-ESO-1-overexpressing tumor cells. This may result in the
specific cytotoxic T-lymphocyte (CTL) killing of NY-ESO-1-positive cancer cells. NY-ESO-1,
a tumor-associated antigen (TAA), is found in normal testis and on the surface of
various tumor cell types; the TCR is specific for SLLMWITQC, an NY-ESO-1-derived peptide,
in a complex with human leukocyte antigen (HLA) A2 peptide.;