Autologous Anti-EBV CAR T Cells BRG01

Preferred Label : Autologous Anti-EBV CAR T Cells BRG01;

NCIt synonyms : Autologous Anti-EBV CAR T-cells BRG01; Autologous Anti-EBV CAR-T Cells BRG01;

NCIt definition : A preparation of autologous T-lymphocytes that are genetically engineered to express a chimeric antigen receptor (CAR) targeting an Epstein-Barr virus (EBV) protein, with potential immunostimulating and antineoplastic activities. Upon intravenous administration, the autologous anti-EBV CAR T cells BRG01 targets a specific EBV protein expressed on EBV-positive cancer cells and promotes killing of these cancer cells. EBV infection is associated with various cancers and the expression of certain EBV specific proteins plays a key role in tumor cell proliferation and survival.;

Molecule name : BRG-01; BRG 01;

NCI Metathesaurus CUI : CL1915153;

Details

Origin ID

C200907;

UMLS CUI

C5853325;

Semantic type(s)
- Cell [UMLS semantic type]
chemical_or_drug_affects_cell_type_or_tissue
- Cytotoxic T-Lymphocyte [NCIt concept]
chemical_or_drug_has_mechanism_of_action
- Antigen Sensitization [NCIt concept]
chemical_or_drug_has_physiologic_effect
- Immunopotentiation [NCIt concept]
- T-Cell Activation [NCIt concept]
concept_is_in_subset
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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