NCIt definition : A cancer vaccine consisting of replication-attenuated arenavirus encoding the inactivated
fusion protein of the viral oncoproteins E6 and E7 derived from the human papillomavirus
(HPV) serotype 16, with potential immunomodulating and antineoplastic activities.
Upon administration, HPV 16 E6/E7-encoding arenavirus vaccine HB-202 induces expression
of the E6/E7 proteins and stimulates the host immune system to mount a cytotoxic T-lymphocyte
(CTL) response against tumor cells expressing HPV16 E6 and E7, resulting in tumor
cell lysis. Oncoproteins E6 and E7 play a key role in the development of cervical
intraepithelial neoplasia (CIN) and cervical carcinoma.;