Preferred Label : T1E28z CAR-expressing Autologous CD4-positive T Lymphocytes;
NCIt synonyms : 4ab T1E28z Positive T-cells;
NCIt definition : Autologous CD4 positive T-lymphocytes engineered to express the chimeric antigen receptor
(CAR) T1E28z containing the ErbB ligand, T1E, fused to the hinge region, transmembrane
domain and endodomain of CD28 and the CD3zeta endodomain, with potential immunomodulating
and antineoplastic activities. T1E, a chimeric polypeptide containing the N-terminus
of human transforming growth factor (TGF)-alpha fused to the C-terminus of epidermal
growth factor (EGF), binds to ErbB1 homodimers and heterodimers as well as ErbB2/3
heterodimers, but not to ErbB2 or erbB3 alone. Upon intratumoral administration, the
promiscuous ErbB ligand T1E of the T1E28z CAR-expressing autologous CD4-positive T
lymphocytes binds to the specific ErbB homo- and heterodimers on tumor cells. This
induces selective toxicity in ErbB-expressing tumor cells resulting in tumor cell
lysis. ErbB1, ErbB2 and ErbB3, members of the epidermal growth factor receptor (EGFR)
family of receptor tyrosine kinases, are frequently overexpressed in solid tumors
and play key roles in tumor cell proliferation and tumor angiogenesis.;
NCI Metathesaurus CUI : CL447356;
Origin ID : C106117;
UMLS CUI : C3827871;
Semantic type(s)
- Cell [UMLS semantic type]
- chemical_or_drug_affects_cell_type_or_tissue
- chemical_or_drug_has_mechanism_of_action
- chemical_or_drug_has_physiologic_effect
- concept_is_in_subset
