NCIt synonyms : RNA Anti-CD19 CAR T Cells; RNA CART19;
NCIt definition : Autologous, genetically engineered T-lymphocytes that have been electroporated with
an mRNA encoding for an anti-CD19 chimeric antigen receptor (CAR) consisting of an
anti-CD19 single chain variable fragment (scFv) coupled to the co-stimulatory signaling
domain of 4-1BB (CD137) and the zeta chain of the T-cell receptor CD3 complex (CD3-zeta),
with potential immunomodulating and antineoplastic activities. Upon transfusion, the
RNA electroporated CD19CAR-CD3zeta-4-1BB-expressing autologous T-lymphocytes attach
to cancer cells expressing CD19. This induces selective toxicity against CD19-expressing
tumor cells and causes tumor cell lysis. The 4-1BB co-stimulatory molecule signaling
domain enhances T-cell activation and signaling after recognition of CD19. CD19 antigen
is a B-cell specific cell surface antigen, which is expressed in all B-cell lineage
malignancies.;