Autologous Multiple Antigen-specific T-cells MASE-T

Preferred Label : Autologous Multiple Antigen-specific T-cells MASE-T;

NCIt synonyms : Multiple Antigen Specific Endogenously Derived T Cells; MASE-T Cells; Multiple Antigen-specific Endogenously-derived T-cells;

NCIt definition : A preparation of autologous T-cells targeting multiple antigens expressed by melanoma cells, with potential immunomodulating and antineoplastic activities. Peripheral blood T-cells from the patient are collected, processed with artificial antigen-presenting scaffolds, and enriched and expanded ex-vivo to generate multiple antigen-specific endogenously-derived T-cells (MASE-T) targeting multiple antigens expressed by melanoma cells. Upon administration, the autologous multiple antigen-specific T-cells MASE-T are re-introduced into the patient, where they target and kill melanoma cells expressing these specific antigens.;

Molecule name : MASE-T;

NCI Metathesaurus CUI : CL1663646;

Details

Origin ID

C180908;

UMLS CUI

C5556709;

Semantic type(s)
- Cell [UMLS semantic type]
chemical_or_drug_affects_cell_type_or_tissue
- Cytotoxic T-Lymphocyte [NCIt concept]
chemical_or_drug_has_mechanism_of_action
- Antigen Sensitization [NCIt concept]
chemical_or_drug_has_physiologic_effect
- Immunopotentiation [NCIt concept]
- T-Cell Activation [NCIt concept]
concept_is_in_subset
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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